Department of Chemistry at Illinois State University

Tenured and Tenure-Track Faculty


Christopher C. Mulligan

Associate Professor, Analytical Chemistry

Office Address: 327A Science Laboratory Building
Office Phone: (309) 438-2464
Office Hours: W 1:30-2:30 p.m. and by appointment
Email: Contact Christopher Mulligan (cmullig)
Website: Visit Christopher Mulligan’s Website
Teaching Schedule:
Course NumberSectionCourse NameTimeRoom NumberCourse Links
CHE216.04Analytical Chemistry Laboratory W 15:00 - 17:50SLB 0228
CHE290.013Research in Chemistry   
CHE299.013Independent Honor Study in Chemistry   
CHE490.013Research in Chemistry   
Teaching Interests:
  • Analytical Chemistry (CHE 215)
  • Mass Spectrometry: Instrumentation and Applications
  • Forensic Chemistry
Research Interests:
  • Design/construction of portable mass spectrometric (MS) systems and ionization sources
  • Conventional and ambient ionization methods:
    • Electrospray (ESI)
    • Atmospheric Pressure Chemical Ionization (APCI)
    • Desorption Electrospray Ionization (DESI)
    • Low-Temperature Plasma (LTP) Ionization 
  • Applications for on-site analysis with portable MS instrumentation:
    • Groundwater contaminants
    • Toxic industrial compounds and gaseous chemical warfare agents in urban air
    • Analysis of explosive traces on suspicious materials
    • Rapid analysis of alkaloids, active chemicals from plant tissues
    • Forensic analysis

    Application Areas: Homeland and Transportation Security, Forensic Analysis, Environmental Monitoring, Industrial Hygiene, Toxicology

  • Education:
    Selected Publications:
    C. R. Wilson, C. C. Mulligan, K. D. Strueh, G. W. Stevenson, S. B. Hooser, "Rapid Detection of Terbufos in Stomach Contents Using Desorption Electrospray Ionization Mass Spectrometry," Journal of Veterinary Diagnostic Investigation, 2014, 26 (3), 428-430. doi:10.1177/1040638714528176

    I. S. Campbell, A. T. Ton, C. C. Mulligan, "Direct Detection of Pharmaceuticals and Personal Care Products from Aqueous Samples with Thermally-Assisted Desorption Electrospray Ionization Mass Spectrometry," Journal of the American Society for Mass Spectrometry, 2011, 22 (7), 1285-1293. doi:10.1007/s13361-011-0144-6

    T. Schwarz, T. A. Snow, C. J. Santee, C. C. Mulligan, T. Class, M. P. Wadsley, S. C. Nanita, "QuEChERS Multiresidue Method Validation and Mass Spectrometric Assessment for the Novel Anthranilic Diamide Insecticides Chlorantraniliprole and Cyantraniliprole," Journal of Agricultural and Food Chemistry, 2011, 59 (3), 814-821. doi:10.1021/jf103468d

    S. A. Smith, C. C. Mulligan, Q. Song, R. J. Noll, R. G. Cooks, Z. Ouyang, "Ion Traps for Miniature, Multiplexed, and Soft-Landing Technologies," in Practical Aspects of Trapped Ion Mass Spectrometry, Vol. IV: Theory and Instrumentation, March, R. E.; Todd, J. F. J., Eds.; CRC Press: Boca Raton, FL, 2010, pp 169-247. doi:10.1201/9781420083729-c2; ISBN: 978-1-4200-8371-2

    J. D. Harper, N. A. Charipar, C. C. Mulligan, X. Zhang, R. G. Cooks, Z. Ouyang, "Low-Temperature Plasma Probe for Ambient Desorption Ionization," Analytical Chemistry, 2008, 80 (23), 9097-9104. doi:10.1021/ac801641a

    N. Talaty, C. C. Mulligan, D. R. Justes, A. U. Jackson, R. J. Noll, R. G. Cooks, "Fabric Analysis by Ambient Mass Spectrometry for Explosives and Drugs," Analyst, 2008, 133 (11), 1532-1540. doi:10.1039/b807934j

    C. Janfelt, N. Talaty, C. C. Mulligan, A. Keil, Z. Ouyang, R. G. Cooks, "Mass Spectra of Proteins and Other Biomolecules Recorded Using a Handheld Instrument," International Journal of Mass Spectrometry, 2008, 278 (2-3), 166-169. doi:10.1016/j.ijms.2008.04.022

    C. C. Mulligan, D. K. MacMillan, R. J. Noll, R. G. Cooks, "Fast Analysis of High-Energy Compounds and Agricultural Chemicals in Water with Desorption Electrospray Ionization Mass Spectrometry," Rapid Communications in Mass Spectrometry, 2007, 21 (22), 3729-3736. doi:10.1002/rcm.3270

    I. Cotte-Rodríguez, C. C. Mulligan, R. G. Cooks, "Non-Proximate Detection of Small and Large Molecules by Desorption Electrospray Ionization and Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry: Instrumentation and Applications in Forensics, Chemistry, and Biology," Analytical Chemistry, 2007, 79 (18), 7069-7077. doi:10.1021/ac0707939

    C. C. Mulligan, N. Talaty, R. G. Cooks, "Desorption Electrospray Ionization with a Portable Mass Spectrometer: in situ Analysis of Ambient Surfaces," Chemical Communications, 2006, 1709-1711. doi:10.1039/b517357d

    I. Cotte-Rodríguez, D. R. Justes, S. C. Nanita, R. J. Noll, C. C. Mulligan, N. L. Sanders, R. G. Cooks, "Analysis of Gaseous Toxic Industrial Compounds and Chemical Warfare Agent Simulants by Atmospheric Pressure Ionization Mass Spectrometry," Analyst, 2006, 131 (4), 579-589. doi:10.1039/b513605a

    C. C. Mulligan, D. R. Justes, R. J. Noll, N. L. Sanders, B. C. Laughlin, R. G. Cooks, "Direct Monitoring of Toxic Compounds in Air Using a Portable Mass Spectrometer," Analyst, 2006, 131 (4), 556-567. doi:10.1039/b517541k

    B. C. Laughlin, C. C. Mulligan, R. G. Cooks, "Atmospheric Pressure Ionization in a Miniature Mass Spectrometer," Analytical Chemistry, 2005, 77 (9), 2928-2939. doi:10.1021/ac0481708