Department of Chemistry at Illinois State University

Tenured and Tenure-Track Faculty

Cedeno

David L Cedeno

Professor, Physical Chemistry

Office Address: 211 Science Laboratory Building
Office Phone: (309)438-5595
Office Hours: MW 10-11 a.m. and by appointment
Email: Contact David Cedeno (dcedeno)
Website: Visit David Cedeno’s Website
Teaching Schedule:
Course NumberSectionCourse NameTimeRoom NumberCourse Links
CHE290.02Research in Chemistry   
CHE299.02Independent Honor Study in Chemistry   
CHE360.01Physical Chemistry I M W F 09:00 - 09:50JH 0225
CHE363.01Physical Chemistry Laboratory II T 09:00 - 11:50SLB 0224
CHE363.02Physical Chemistry Laboratory II R 15:00 - 17:50SLB 0224
CHE363.03Physical Chemistry Laboratory II R 09:00 - 11:50SLB 0224
CHE490.02Research in Chemistry   
Teaching Interests:
Physical Chemistry and General Chemistry
See http://my.ilstu.edu/~dcedeno/
Research Interests:

The Cedeno group is involved in the following research projects:

1. Bonding in metal-alkene complexes
I am interested in developing a quantitative model that is based on a complete understanding on how metals interact and bond with olefins. Our current investigations deal with understanding how different modifications in the olefin structure influence its interaction with various transitions metal complexes. We employ laser-based calorimetric methods and infrared spectroscopy to measure metal-olefin bond strengths in a series of model metal complexes. The experiments are complemented with computational methods (density functional theory, DFT) that allow us to unravel the metal-olefin interaction in terms of electronic, steric, and reorganizational effects. We have already found that trends in the metal-olefin bond strengths of some systems are quite different to what is predicted by the current model (Dewar-Chatt-Duncanson). For instance, using the current model, it is usually predicted that an olefin that is able to attract electrons strongly will bond to a metal stronger than an olefin that attracts electrons poorly. We have demonstrated that, even though electron attracting olefins are good at interacting with a metal, the interaction induces a structural change in the olefin that is, in many cases, energetically costly. The effect of such reorganization is to weaken the metal-olefin bond and destabilize the metal-olefin complex

2. Photophysical properties of photosensitizers and their potential application in the photodynamic treatment of leishmaniasis
The treatment of diseases by photoactivation of a compound that induces the destruction of pathogens or unhealthy cells is an alternative in the medical field. From chemical principles, the methodology relies on the ability of a compound on absorbing light and being able to get to a state that induces the formation of reactive oxygen species (ROS). Part of our research efforts deals with investigating how alterations in the molecular structure of novel porphyrins (synthesized and kindly supplied by T.D. Lash, Illinois State U.) and its chemical environment affect their photophysical properties and ability to produce ROS.

More recently our efforts have focused on studying the potential use of porphyrins and porphyrinoids in the photodynamic treatment of cutanesous and Mucocutaneous leishmaniasis. This is a parasitic disease affecting twelve million people in 88 countries around the world. Our interdisciplinary efforts in this area are part of a collaborative enterprise that involve scientists at Illinois State U. (Program of Excellence team: D. Cedeño, T. Lash, M. Jones) and the Program for the Study and Control of Tropical Diseases at the Universidad de Antioquia (S. Robledo, I. Velez) in Medellin, Colombia. Recent in vitro and in vivo results indicate that two novel compounds are promising leishmanicides. Current and future research focuses on the formulation of the compounds in sub-micron sized delivery systems to enhance their selectivity.

Common Experimental Techniques:

  • Steady state spectrophotometry (UV-vis absorption and emission)
  • FTIR Spectroscopy
  • Laser Photoacoustic Calorimetry
  • Laser Flash Photolysis
  • Near Infrared Laser Spectroscopy
  • Organic synthesis: small molecules
  • Encapsulation of photosensitizers in sub-micron sized delivery systems
  • Confocal fluorescence microscopy
  • Scanning electron microscopy
Education:
B.S. Chemistry, 1991, Universidad del Valle, Colombia
Ph.D. Chemistry, 1999, Baylor University
Post-doctoral, 1999-2001, Northwestern University
Selected Publications:
J. D. Hooker, V. H. Nguyen, V. M. Taylor, D. L. Cedeño, T. D. Lash, M. A. Jones, S. M. Robledo, I. D. Vélez, “New Application for Expanded Porphyrins: Sapphyrin and Heterosapphyrins as Inhibitors of Leishmania Parasites,” Photochemistry and Photobiology, 2012, 88 (1), 194-200. doi:10.1111/j.1751-1097.2011.01034.x

V. M. Taylor, D. L. Cedeño, S. M. Robledo, "Fototerapia para el tratamiento de la leishmaniasis cutanea" Infectio, 2011, 15 (4), 277-288. http://www.revistainfectio.org/site/portals/0/ojs/index.php/infectio/article/view/475

V. M. Taylor, D. L. Cedeño, D. L. Muñoz, M. A. Jones, T. D. Lash, A. M. Young, M. H. Constantino, N. Esposito, I. D. Vélez, S. M. Robledo, “In Vitro and In Vivo Studies of the Utility of Dimethyl and Diethyl Carbaporphyrin Ketals in Treatment of Cutaneous Leishmaniasis,” Antimicrobial Agents and Chemotherapy, 2011, 55 (10), 4755-4764. doi:10.1128/aac.00671-11

L. F. Szczepura, D. L. Cedeño, D. B. Johnson, R. McDonald, S. A. Knott, K. M. Jeans, J. L. Durham, "Substitution of the Terminal Chloride Ligands of [Re6S8Cl6]4- with Triethylphosphine: Photophysical and Electrochemical Properties of a New Series of [Re6S8]2+ Based Clusters," Inorganic Chemistry, 2010, 49 (24), 11386-11394. doi:10.1021/ic101348h

V. M. Taylor, D. L. Muñoz, D. L. Cedeño, I. D. Vélez, M. A. Jones, S. M. Robledo, “Leishmania Tarentolae: Utility as an In Vitro Model for Screening of Antileishmanial Agents,” Experimental Parasitology, 2010, 126 (4), 471-475. doi:10.1016/j.exppara.2010.05.016

D. L. Cedeño, M. A. Jones, J. A. Friesen, M. W. Wirtz, L. A. Ríos, G. T. Ocampo, “Integrating Free Computer Software in Chemistry and Biochemistry Instruction: An International Collaboration,” Journal of Science Education and Technology, 2010, 19 (5), 434-437. doi:10.1007/s10956-010-9209-8

D. M. Gardner, V. M. Taylor, D. L. Cedeño, S. Padhee, S. M. Robledo, M. A. Jones, T. D. Lash, I. D. Vélez, “Association of Acenaphthoporphyrins with Liposomes for the Photodynamic Treatment of Leishmaniasis,” Photochemistry and Photobiology, 2010, 86 (3), 645-652. doi:10.1111/j.1751-1097.2010.00705.x

D. N. Schlappi, D. L. Cedeño, “Metal-Olefin Bond Energies in M(CO)5(C2H4-nCln) M = Cr, Mo, W; n = 0-4: Electron-Withdrawing Olefins Do Not Increase the Bond Strength,” Journal of Physical Chemistry A, 2009, 113 (35), 9692-9699. doi:10.1021/jp9027468

L. F. Szczepura, J. A. Edwards, D. L. Cedeño, “Luminescent Properties of Hexanuclear Molybdenum(II) Chloride Clusters Containing Thiolate Ligands,” Journal of Cluster Science, 2009, 20 (1), 105-112. doi:10.1007/s10876-008-0214-5

T. Chávez-Gil, D. L. Cedeño, C. G. Hamaker, M. Vega, J. Rodriguez, “Synthesis, Characterization, and Crystal Structure of [Cu{(3,5-Ph2Pz)2BH2}2]0: Evidence of a B-H-Cu Agostic Interaction,” Journal of Molecular Structure, 2008, 888 (1-3), 168-172. doi:10.1016/j.molstruc.2007.11.044

L. F. Szczepura, K. A. Ketcham, B. A. Ooro, J. A. Edwards, J. N. Templeton, D. L. Cedeño, A. J. Jircitano, "Synthesis and Study of Hexanuclear Molybdenum Clusters Containing Thiolate Ligands," Inorganic Chemistry, 2008, 47 (16), 7271-7278. doi:10.1021/ic800613d

J. B. Morgenthaler, S. J. Peters, D. L. Cedeño, M. H. Constantino, K. A. Edwards, E. M. Kamowski, J. C. Passini, B. E. Butkus, A. M. Young, T. D. Lash, M. A. Jones, “Carbaporphyrin Ketals as Potential Agents for a New Photodynamic Therapy Treatment of Leishmaniasis,” Bioorganic and Medicinal Chemistry, 2008, 16 (14), 7033-7038. doi:10.1016/j.bmc.2008.05.037

R. D. Parra, D. L. Cedeño, “Preferred Conformations of the Gas Phase Complex Between Li+ and a Model Macrocycle Tetraamide,” Journal of Molecular Structure: THEOCHEM, 2007, 819 (1-3), 79-87. doi:10.1016/j.theochem.2007.05.024

L. C. Kismartoni, E. Weitz, D. L. Cedeño, “Density Functional Study of Fe(CO)3 and Fe(CO)3(L) with H2 and C2H4, where L = H2 or C2H4: Reactions Relevant to Olefin Hydrogenation,” Organometallics, 2005, 24 (20), 4714-4720. doi:10.1021/om0499411

D. L. Cedeño, R. Sniatynsky, “Metal-Olefin Interactions in M(CO)5(cycloolefin) (M = Cr, Mo, W; Cycloolefin = Cyclopropene to Cyclooctene): Strain Relief and Metal-Olefin Bond Strength,” Organometallics, 2005, 24 (16), 3882-3890. doi:10.1021/om050331q

D. L. Cedeño, E. Weitz, “Reactions of Fe(CO)4 with C2H5I in the Gas Phase: Evidence for the Formation of IFe(CO)4(C2H5), IFe(CO)3(η2-COC2H5), and IFe(CO)4(COC2H5),” Organometallics, 2005, 24 (6), 1233-1241. doi:10.1021/om0492348

R. Sniatynsky, D. L. Cedeño, “A Density Functional Theory Benchmark of the Formation Enthalpy and First CO Dissociation Enthalpy of Hexacarbonyl Complexes of Chromium, Molybdenum, and Tungsten,” Journal of Molecular Structure: THEOCHEM, 2004, 711 (1-3), 123-131. doi:10.1016/j.theochem.2004.09.018

D. N. Schlappi, D. L. Cedeño, “Electron-Withdrawing Effects on Metal-Olefin Bond Strengths in Ni(PH3)2(CO)(C2XnH4-n), X = F, Cl; n = 0-4: A DFT Study,” Journal of Physical Chemistry A, 2003, 107 (41), 8763-8773. doi:10.1021/jp0357572

D. L. Cedeño, E. Weitz, “Density Functional Theory Study of Fe(CO)3(η2-C3H6), HFe(CO)3(η3-C3H5), and the Iron-Allyl Bond Energy,” Organometallics, 2003, 22 (13), 2652-2659. doi:10.1021/om020920l

D. L. Cedeño, E. Weitz, “An Experimental Determination of the Cr-DMB (DMB = 3,3-Dimethyl-1-butene) Bond Energy in Cr(CO)5(DMB): Effects of Alkyl Substitution on Chromium-Olefin Bond Energies in Cr(CO)5(olefin) Complexes,” Journal of Physical Chemistry A, 2002, 106 (18), 4651-4660. doi:10.1021/jp013912b

D. L. Cedeño, E. Weitz, “Experimental Determination of the Cr-C2Cl4 Bond Dissociation Enthalpy in Cr(CO)5(C2Cl4): Quantifying Metal-Olefin Bonding Interactions,” Journal of the American Chemical Society, 2001, 123 (51), 12857-12865. doi:10.1021/ja011643x

D. L. Cedeño, E. Weitz, A. Bérces, “Bonding Interactions in Olefin (C2X4, X = H, F, Cl, Br, I, CN) Iron Tetracarbonyl Complexes: Role of the Deformation Energy in Bonding and Reactivity,” Journal of Physical Chemistry A, 2001, 105 (34), 8077-8085. doi:10.1021/jp011392e

D. L. Cedeño, E. Weitz, A. Bérces, “Bond Energies and Bonding Interactions in Fe(CO)5-n(N2)n (n = 0-5) and Cr(CO)6-n(N2)n (n = 0-6) Complexes: Density Functional Theory and Comparisons to Experimental Data,” Journal of Physical Chemistry A, 2001, 105 (15), 3773-3787. doi:10.1021/jp003097k

E. K. Lewis, D. Reynolds, X. Li, G. deVillele, C. Leduc, D. L. Cedeño, C. Manzanaresl, “Phase Shift Cavity Ring-Down Measurement of C-H (Δv = 6) Vibrational Overtone Absorptions,” Chemical Physics Letters, 2001, 334 (4-6), 357-364. doi:10.1016/S0009-2614(00)01466-4