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Dr. Jon Friesen

Professor, Biochemistry
Chemistry
Office
Science Laboratory Building - SLB 318
Office Hours
Wed. 9-10:30am
  • About
  • Education
  • Awards & Honors
  • Research

Current Courses

342.001General Biochemistry I

140.003General Chemistry I

299.057Independent Honor Study

299.005Independent Honor Study In Chemistry

499.005Independent Research For The Master's Thesis

492.001Literature Seminar In Chemistry

440.001Nucleic Acids

290.005Research in Chemistry

490.005Research In Chemistry

494.001Research Seminar In Chemistry

242.001Basic Biochemistry

Research Interests & Areas

In my laboratory we use modern molecular biological tools as well as classical biochemical techniques to study the structure and function of enzymes critical for the biosynthesis of phosphatidylcholine, a major phospholipid component of the eukaryotic cell membrane. Research focuses on the enzyme CTP:phosphocholine cytidylyltransferase (CT), a member of the CDP-choline pathway, which results in the biosynthesis of phosphatidylcholine (PC). PC is the major component of eukaryotic cell membranes and a precursor to vital components of signal transduction pathways such as diacylglycerol and phosphatidic acid. CT is rate-limiting for the CDP-choline pathway and extensively regulated at the cellular level. CT is present as both a soluble and membrane-associated form. In many cells, activation of CT occurs simultaneously with the translocation of the enzyme from a soluble form to membrane-associated form, while in vitro the soluble form of CT is activated by the addition of certain lipids. In addition to regulation via association with membranes, CT from mammals is extensively phosphorylated. The regulation of CT activity is central to a variety of cellular processes, including the cell cycle, cell death, and vesicular traffic.

Ph D Biochemistry

Purdue University
West lafayette, Indiana

BA Chemistry

Bluffton University
Bluffton, Ohio

Other

Bowling Green State University

Faculty Invitee

Academic Excellence Award Banquet, Athletics
2019

Faculty Invitee

Academic Excellence Award Banquet, Athletics
2017

Impact Award

University College, ISU
2017

Faculty Invitee

Academic Excellence Award Banquet, Athletics
2016

Faculty Invitee

Academic Excellence Award Banquet, Athletics
2015

Faculty Appreciation Award

Red Tassel Chapter, ISU
2014

John A. Dossey Award for Outstanding Teaching by a Tenured Faculty Member

Illinois State University College of Arts and Sciences
2011

Faculty Appreciation Award

Red Tassel Chapter, ISU
2010

Faculty Appreciation Award

Red Tassel Chapter, ISU
2010

Faculty Invitee

Academic Excellence Award Banquet, Athletics
2010

Journal Article

Walker, J., Friesen, J., Peters, S., Jones, M., & Friesen, J. Development of a new and reliable assay for choline kinase using P-31 NMR. HELIYON 5.10 (2019)
Pulido, S., Nguyen, V., Alzate, J., Cedeño, D., Makurath, M., Ríos-Vásquez, A., Duque-Benítez, S., Jones, M., Robledo, S., & Friesen, J. Insights into the phosphatidylcholine and phosphatidylethanolamine biosynthetic pathways in Leishmania parasites and characterization of a choline kinase from Leishmania infantum.. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 213 (2017): 45-54.
Brault, J., & Friesen, J. Characterization of cytidylyltransferase enzyme activity through high performance liquid chromatography.. Analytical biochemistry 510 (2016): 26-32.
Hughes, S., Moser, B., Robinson, S., Cox, E., Harmsen, A., Friesen, J., Bischoff, K., Jones, M., Pinkelman, R., Bang, S., Tasaki, K., Doll, K., Qureshi, N., Liu, S., Saha, B., Jackson, J., Cotta, M., Rich, J., & Caimi, P. Synthetic resin-bound truncated Candida antarctica lipase B for production of fatty acid alkyl esters by transesterification of corn and soybean oils with ethanol or butanol.. Journal of biotechnology 159.1-2 (2012): 69-77.
Mericl, A., & Friesen, J. Comparative kinetic analysis of glycerol 3-phosphate cytidylyltransferase from Enterococcus faecalis and Listeria monocytogenes.. Medical science monitor : international medical journal of experimental and clinical research 18.11 (2012): BR427-34.

Presentations

Comparative Kinetic Analysis of Bacterial Cytidylyltransferases. American Chemical Society National Meeting. ACS. (2011)
Comparative Kinetic Analysis of Bacterial Cytidylyltransferases. Illinois State University Graduate Research Symposium. ISU. (2011)
Molecular Modeling Exercises to Enhance Biochemical Learning. Illinois State University Teaching and Learning Symposium. ISU. (2011)

Grants & Contracts

Phospholipid Synthesis in Protozoa. National Science Foundation. Federal. (2010)
RUI Individual Research Grant. National Science Foundation (NSF). Federal. (2010)
Teaching and Learning Development Grant. Center for Teaching, Learning and Technology at Illinois State University. Illinois State University. (2010)
SFF. College of Arts and Sciences. Illinois State University. (2007)
Teaching Development Travel Grant. CTLT. Illinois State University. (2006)