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Dr. Andy Mitchell

Professor, Organic Chemistry
Office
SLB Science Lab Building 219
Office Hours
Tues. & Thurs. 3-4
  • About
  • Education
  • Awards & Honors
  • Selected Research

Biography

Andy Mitchell obtained a B.S. in Chemistry at Grove City College (PA) in 2001. He joined the research group of Prof. Daniel Romo at Texas A&M University and completed his Ph.D. in 2008. After two years as a postdoctoral associate with Prof. Jeffrey W. Bode at the University of Pennsylvania, he joined the Department of Chemistry at Illinois State University as an Assistant Professor in 2010 and was promoted to Associate Professor with Tenure in 2016 and promoted to Professor in 2021.

Current Courses

CHE 299.014 Independent Honor Study In Chemistry

CHE 499.014 Independent Research For The Master's Thesis

CHE 232.001 Organic Chemistry II

CHE 231.003 Organic Chemistry Laboratory I

CHE 290.014 Research in Chemistry

CHE 490.014 Research In Chemistry

Teaching Interests & Areas

Organic Chemistry

Research Interests & Areas

Often referred to as the central science, chemistry continues to demonstrate utility toward a wide range of scientific disciplines. The development of new reactions occupies a privileged position within the field of chemistry due to extensive applications derived from organic synthesis. Since pioneering syntheses of urea (1828) and acetic acid (1845), organic synthesis has impacted countless technological advances. The theme of our research program is natural product inspired organic synthesis - an enduring training ground for next generation scientists. Our group focuses on the development of new reactions that are either inspired by or directed toward natural products. Several oxidopyrylium-alkene [5+2] cycloadditions are under investigation since the products, bridged polycyclic ethers, are ubiquitous moieties in biologically active natural products. Students learn a variety of skills in this research including laboratory techniques, mechanistic reasoning, interpretation of spectra, and presentation of results.

Ph D Chemistry

Texas A&M University
College Station, TX 77840

BS Chemistry

Grove City College
Grove City, PA 16127

Research Grant – Chemical Synthesis (RUI) – CHE-1954588

National Science Foundation
2020

Early Career Chemist Award

American Chemical Society Illinois Heartland Local Section
2020

Research Grant – Chemical Synthesis (RUI) – CHE-1565644

National Science Foundation
2016

Red Tassel Mortar Board Faculty Appreciation Award

Illinois State University
2014

University Research Initiative Award

Illinois State University
2014

Major Research Instrumentation Award (Co-PI) – CHE-1337497

National Science Foundation
2013

University Research Grant, Faculty Research Award

Illinois State University
2013

Cottrell College Science Award

Research Corporation for Science Advancement
2012

Undergraduate New Investigator Grant

American Chemical Society Petroleum Research Fund
2012

University Research Grant, Pre-Tenure Faculty Initiative

Illinois State University
2012

Grant-Writing Mentorship Program

Illinois State University College of Arts and Sciences
2011

University Research Grant, New Faculty Initiative

Illinois State University
2011

Full Membership of the Graduate Faculty

Department of Chemistry
2010

Grants and Contracts

RUI: Nitrogen as an Enabling Linchpin for Complexity-Building Based on (5+2) Cycloadditions
Timothy Andrew Mitchell.
National Science Foundation. August 1 2024 - July 31 2027
Silyloxypyrone-Based [5+2] Cycloadditions: Mechanism, Methods, and Mentorship
Timothy Andrew Mitchell.
National Science Foundation (RUI): CHE-1954588. September 1 2020
Exploration of Cycloadditions toward Novel Heterocyclic Scaffolds
Timothy Andrew Mitchell.
National Science Foundation (RUI): CHE-1565644. September 1 2016 - August 31 2020
Stereoselective N-Heterocyclic Carbene (NHC): Catalyzed Oxidopyrylium-Enolate [5+2] Cycloadditions toward Bridged, Polycyclic Ethers
Timothy Andrew Mitchell.
American Chemical Society - Petroleum Research Foundation (UNI). October 2012 - September 2015
Toward the Building Blocks for the Convergent Total Synthesis of Muironolide A
Timothy Andrew Mitchell.
Research Corporation for Science Advancement (Cottrell College Award). July 2012 - June 2015

Journal Article

Efforts toward the total synthesis of (±)-toxicodenane A utilizing an oxidopyrylium-based [5 + 2] cycloaddition of a silicon-tethered BOC-pyranone
Jake P Grabowski, Gregory M Ferrence, T. A Mitchell.
Tetrahedron Letters, 61, 152324, (2020)
Intramolecular asymmetric oxidopyrylium-based [5 + 2] cycloadditions
Samantha N Rokey, Justin A Simanis, Law M Chunyin, Shilpa Pohani, Samantha Willens Behrends, Jacob J Bulandr, Gregory M Ferrence, John R Goodell, T. Andrew Mitchell.
Tetrahedron Letters, 61, 152377, (2020), 10.1016/j.tetlet.2020.152377
Investigation of Transfer Group, Tether Proximity and Alkene Substitution for Intramolecular Silyloxypyrone-Based [5 + 2] Cycloadditions
Jacob J Bulandr, Jacob P Grabowski, Chunyin M Law, Jessica L Shaw, John R Goodell, Timothy Andrew Mitchell.
Journal of Organic Chemistry, 84, 10306-10320, (2019)
Oxidopyrylium-Alkene [5 + 2] Cycloaddition Conjugate Addition Cascade (C3) Sequences: Scope, Limitation, and Computational Investigations
Riley H Kaufman, Chunyin M Law, Justin A Simanis, Erica L Woodall, Christian R Zwick, III, Henry B Wedler, Paul Wendleboe, Christopher G Hamaker, John R Goodell, Dean J Tantillo, Timothy Andrew Mitchell.
Journal of Organic Chemistry, 83, 9818-9838, (2018)
Further Investigation of Pyranone Activation
Justin A Simanis, Christian R Zwick, III, Erica L Woodall, John R Goodell, Timothy Andrew Mitchell.
Heterocycles, 91, 149-156, (2015)
Hexahydro-1H-Isoindolinone-Like Scaffolds from Electronically Deactivated and Sterically Hindered Dienes; Synthesis in the Context of Muironolide A
Christopher A Olson, Courtnay E Shaner, Sydney C Roche, Gregory M Ferrence, Timothy Andrew Mitchell.
Synthesis, 47, 2756-2766, (2015)
Investigation of Oxidopyrylium-Alkene [5+2] Cycloaddition Conjugate Addition Cascade (C3) Sequences
Justin A Simanis, Chunyin M Law, Erica L Woodall, Christopher G Hamaker, John R Goodell, Timothy Andrew Mitchell.
Chemical Communications, 50, 9130-9133, (2014)
Synthetic efforts toward the isoindolinone core of muironolide A
Courtnay E. Shaner, Gregory M. Ferrence, T. Andrew Mitchell.
Synlett, 24 (14), 1861-1864, (2013)
Unique Reactivity of anti- and syn-Acetoxypyranones en route to Oxidopyrylium Intermediates Leading to a Cascade Process
Erica L Woodall, Justin A Simanis, Christopher G Hamaker, John R Goodell, Timothy Andrew Mitchell.
Organic Letters, 15, 3270-3273, (2013)
Expanded Substrate Scope and Improved Reactivity of Ether-Forming Cross-Coupling
C. -V. Vo, Timothy Andrew Mitchell, J. W. Bode.
J. Am. Chem. Soc., 133, 14082-14089, (2011)

Manuscript

Experimental and Theoretical Investigation of the Synchronicity of Ambident Silyloxypyrone-Based (5 + 2) Cycloadditions
Adam J Youman, Samantha N Rokey, Jacob P Grabowski, Wentao Guo, Qing Sun, Susanna N Angles, John R Goodell, Dean J Tantillo, Timothy Andrew Mitchell.
The Journal of Organic Chemistry, 88 (2023), 5972-5981, (2023), https://pubs.acs.org/doi/10.1021/acs.joc.3c00318
Net Intermolecular Silyloxypyrone-Based (5+2) Cycloadditions Utilizing Amides as Enabling and Cleavable Tethers
Susanna N Angles, Wentao Guo, Kwabena Darko, Marymoud Erzuah, Kenneth G Pauley, Ifeanyichukwu E Promise, John R Goodell, Dean J Tantillo, Timothy Andrew Mitchell.
Organic Letters, 25 (2023), 7137-7141, (2023), https://doi.org/10.1021/acs.orglett.3c02635
Boron-tethered oxidopyrylium-based [5 + 2] cycloadditions
Seth I Corrie, Aaron C Pearce, Jacob P Grabowski, Kee A Randolph, Wentao Guo, Dean J Tantillo, Timothy Andrew Mitchell.
Tetrahedron Letters, 107 (2022), 154094, (2022), https://doi.org/10.1016/j.tetlet.2022.154094